Chemistry Heterocyclic Building Blocks Pyrimidines Thieno[3,2-D]Pyrimidine

Thieno[3,2-D]Pyrimidine

Reduction Reactions: Thieno[3,2-d]pyrimidine can be reduced using various reducing agents to obtain saturated or partially saturated derivatives. For example, catalytic hydrogenation or reduction with metal hydrides like lithium aluminum hydride (LiAlH4) can lead to reduced products. Oxidation Reactions: Thieno[3,2-d]pyrimidine can be oxidized to produce various functional groups. Oxidation with reagents like potassium permanganate (KMnO4) or chromium(VI) compounds can lead to the formation of ketones, aldehydes, or other oxidized products. Nucleophilic Substitution: The nitrogen atom in thieno[3,2-d]pyrimidine can undergo nucleophilic substitution reactions with appropriate nucleophiles. For example, primary or secondary amines can substitute the nitrogen atom to form various derivatives. Ring Opening Reactions: Thieno[3,2-d]pyrimidine can undergo ring-opening reactions under certain conditions. This can lead to the formation of open-chain compounds with reactive functional groups. Cyclization Reactions: Thieno[3,2-d]pyrimidine can serve as a starting material for the synthesis of other heterocyclic compounds through cyclization reactions. For instance, it can be used as a precursor in the synthesis of fused heterocycles. Cross-Coupling Reactions: Thieno[3,2-d]pyrimidine can participate in cross-coupling reactions with various electrophiles or nucleophiles, leading to the formation of biologically active molecules or functionalized derivatives. Functional Group Transformations: You can introduce and modify functional groups on the thieno[3,2-d]pyrimidine ring through a variety of reactions such as esterification, amidation, alkylation, and acylation.

Further Reading:

Framework+−

(R)-7-(Tetrahydrofuran-2-Yl)-7H-Pyrrolo[2,3-D]Pyrimidine (R)-N-(Piperidin-3-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine 1,4,5,6-Tetrahydropyrimidine 1-(3-Fluorotetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 1-(5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione 1-(Pyrimidin-2-Yl)Ethan-1-One 1-(Pyrimidin-4-Yl)Ethan-1-One 1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine 1H-Pyrazolo[4,3-D]Pyrimidine 2,4,5-Trichloropyrimidine 2,4,6-Trichloropyrimidine 2,4,6-Triphenylpyrimidine 2,4-Dichloro-6-Methylpyrimidine 2,4-Dichloropyrimidin-5-Amine 2,4-Dimethoxypyrimidine 2,4-Dimethylpyrimidine 2-(1H-Pyrazol-1-Yl)Pyrimidine 2-(Chloromethyl)Pyrimidine 2-(Methylsulfonyl)Pyrimidine 2-(Methylthio)Pyrimidin-4-Amine 2-(Methylthio)Pyrimidine 2-(Piperazin-1-Yl)Pyrimidine 2-(Piperidin-1-Yl)Pyrimidine 2-(Propylthio)Pyrimidine 2-(Pyridin-2-Yl)Pyrimidine 2-(Pyrrolidin-1-Yl)Pyrimidine 2-(Trifluoromethyl)Pyrimidine 2-Aminopyrimidin-4(3H)-One 2-Bromopyrimidine 2-Chloro-4-(Trifluoromethyl)Pyrimidine 2-Chloro-4-Methoxypyrimidine 2-Chloro-4-Methylpyrimidine 2-Chloro-4-Phenylpyrimidine 2-Chloro-5-Fluoropyrimidine 2-Chloro-5-Methylpyrimidine 2-Chloro-5-Nitropyrimidine 2-Chloro-7H-Pyrrolo[2,3-D]Pyrimidine 2-Chloropyrimidin-4-Amine 2-Cyclopropylpyrimidine 2-Ethoxypyrimidine 2-Ethylpyrimidine 2-Fluoropyrimidine 2-Hydrazineylpyrimidine 2-Iodopyrimidine 2-Methoxypyrimidin-4-Amine 2-Methoxypyrimidine 2-Methylpyrimidin-4-Amine 2-Methylpyrimidin-4-Ol 2-Phenoxypyrimidine 2-Phenylpyrimidin-5-Amine 3-Methylpyrimidin-4(3H)-One 4,5-Dichloropyrimidine 4,6-Dichloro-2-(Methylthio)Pyrimidine 4,6-Dichloro-2-Methylpyrimidine 4,6-Dichloropyrimidin-2-Amine 4,6-Dichloropyrimidine 4,6-Diphenylpyrimidine 4-(Dimethoxymethyl)Pyrimidine 4-(Piperazin-1-Yl)Pyrimidine 4-(Piperidin-1-Yl)Pyrimidine 4-(Pyridin-3-Yl)Pyrimidine 4-(Pyrimidin-2-Yl)Morpholine 4-(Pyrimidin-4-Yl)Morpholine 4-(Trifluoromethyl)Pyrimidin-2-Amine 4-(Trifluoromethyl)Pyrimidine 4-Amino-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 4-Bromopyrimidine 4-Chloro-2-(Methylthio)Pyrimidine 4-Chloro-2-Methoxypyrimidine 4-Chloro-2-Phenylpyrimidine 4-Chloro-5-Fluoro-2-Methylpyrimidine 4-Chloro-5-Iodopyrimidine 4-Chloro-5-Methoxypyrimidine 4-Chloro-5-Methylpyrimidine 4-Chloro-6-Methoxypyrimidine 4-Chloropyrimidin-2-Amine 4-Chloropyrimidin-5-Amine 4-Chloropyrimidine-5-Carbonitrile 4-Ethoxypyrimidine 4-Fluoropyrimidine 4-Iodopyrimidine 4-Methoxy-2-Methylpyrimidine 4-Methoxypyrimidin-2-Amine 4-Methoxypyrimidine 4-Methyl-2-(Methylthio)Pyrimidine 4-Methylpyrimidin-2-Amine 4-Methylpyrimidine 4-Phenoxypyrimidine 4-Phenylpyrimidin-2-Amine 5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine 5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidine 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine 5-(Benzyloxy)Pyrimidine 5-Benzylpyrimidine 5-Bromo-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione 5-Bromo-2-(Methylthio)Pyrimidine 5-Bromo-2-Chloropyrimidine 5-Bromo-2-Methylpyrimidine 5-Bromo-4-Chloropyrimidine 5-Bromo-7H-Pyrrolo[2,3-D]Pyrimidine 5-Bromopyrimidin-4(3H)-One 5-Chloropyrimidin-4(3H)-One 5-Chloropyrimidine 5-Chloropyrimidine-2,4(1H,3H)-Dione 5-Ethylpyrimidine 5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidin-2(1H)-One 5-Fluoro-1-(Tetrahydrofuran-2-Yl)Pyrimidine-2,4(1H,3H)-Dione 5-Fluoropyrimidin-4(3H)-One 5-Fluoropyrimidine 5-Fluoropyrimidine-2,4(1H,3H)-Dione 5-Iodo-7H-Pyrrolo[2,3-D]Pyrimidine 5-Iodopyrimidine 5-Methylpyrimidine 5-Phenylpyrimidine 5H-Pyrrolo[3,2-D]Pyrimidine 6,7-Dihydro-5H-Cyclopenta[D]Pyrimidine 6,7-Dihydro-5H-Pyrrolo[3,4-D]Pyrimidine 6-Chloro-1H-Pyrazolo[3,4-D]Pyrimidine 6-Chloropyrimidin-4-Amine 7-(Phenylsulfonyl)-7H-Pyrrolo[2,3-D]Pyrimidine 7H-Pyrrolo[2,3-D]Pyrimidin-2-Amine 7H-Pyrrolo[2,3-D]Pyrimidin-4-Amine [1,2,4]Triazolo[1,5-A]Pyrimidine Ethyl 4-Chloropyrimidine-5-Carboxylate Ethyl Pyrazolo[1,5-A]Pyrimidine-3-Carboxylate Ethyl Pyrimidine-4-Carboxylate Ethyl Pyrimidine-5-Carboxylate Imidazo[1,2-C]Pyrimidine Methyl Pyrimidine-2-Carboxylate Methyl Pyrimidine-4-Carboxylate Methyl Pyrimidine-5-Carboxylate N,N-Dimethylpyrimidin-2-Amine N-(9-((2R,5S)-5-((Trityloxy)Methyl)Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide N-Benzyl-9H-Purin-6-Amine N-Cyclopropylpyrimidin-2-Amine N-Methyl-N-(4-Phenylpyrimidin-2-Yl)Methanesulfonamide N-Methylpyrimidin-2-Amine N-Methylpyrimidin-4-Amine N-Phenyl-4-(Pyridin-3-Yl)Pyrimidin-2-Amine N-Phenylpyrimidin-2-Amine N-Phenylpyrimidin-4-Amine N2,N4-Diphenylpyrimidine-2,4-Diamine Pyrido[2,3-D]Pyrimidine Pyrido[3,2-D]Pyrimidine Pyrido[3,4-D]Pyrimidine Pyrimidin-2-Ol Pyrimidin-2-Ylmethanamine Pyrimidin-2-Ylmethanol Pyrimidin-4-Amine Pyrimidin-4-Ol Pyrimidin-5-Amine Pyrimidin-5-Ol Pyrimidin-5-Ylboronic Acid Pyrimidine-2,4-Diamine Pyrimidine-2-Carbonitrile Pyrimidine-2-Carboxylic Acid Pyrimidine-2-Thiol Pyrimidine-4,6(1H,5H)-Dione Pyrimidine-4-Carbonitrile Pyrimidine-4-Carboxylic Acid Pyrimidine-5-Carbaldehyde Pyrimidine-5-Carbonitrile Pyrimidine-5-Carboxylic Acid Tetrahydropyrimidin-2(1H)-One Thiazolo[5,4-D]Pyrimidine Thieno[2,3-D]Pyrimidine Thieno[3,2-D]Pyrimidine

By Key Group+−

Allylpyrimidine Amino-Pyrazolopyrimidine Amino-Pyrrolopyrimidine Amino-Triazolopyrimidine Aminopyrimidine Benzofuranopyrimidine Bipyrimidine Bromo-Pyrazolopyrimidine Bromo-Pyrrolopyrimidine Bromo-Trifluoromethyl-Pyrimidine Bromopyrimidine Butylpyrimidine Chloro-Pyrazolopyrimidine Chloro-Pyrrolopyrimidine Chloro-Triazolopyrimidine Chloro-Trifluoromethyl-Pyrimidine Chloropyrimidine Cyclopropylpyrimidine Diaminopyrimidine Dibromopyrimidine Dichloropyrimidine Difluoropyrimidine Dihydropyrimidine Dihydroxy-Pyrimidine Dihydroxypyrimidine Dimethoxypyrimidine Dimethylpyrimidine Dioxaborolan-Pyrimidine Diphenylpyrimidine Ethoxypyrimidine Ethylpyrimidine Fluoropyrimidine Furanopyrimidine Hydrazinylpyrimidine Hydroxy-Pyrazolopyrimidine Hydroxypyrimidine Imidazolyl-Pyrimidine Imidazopyrimidine Iodo-Pyrrolopyrimidine Iodopyrimidine Isopropoxypyrimidine Isopropylpyrimidine Mercaptopyrimidine Methoxypyrimidine Methyl-Triazolopyrimidine Methylpyrimidine Methyluracil Nitropyrimidine Phenoxypyrimidine Phenylpyrimidine Piperazin-Pyrimidin Piperidine-Pyrimidine Propylpyrimidine Pyrazolo-Pyrimidine Pyrazolopyrimid-One Pyrazolopyrimidine Pyridin-Pyrimidin Pyridopyrimidin Pyrimidinamine Pyrimidine-Boronic Acid Pyrimidine-Boronic Acid/Ester Pyrimidine-Boronic-Acid Pyrimidine-Hydrochloride Pyrimidine-Methanol Pyrimidine-Morpholine Pyrimidine-Nitrile Pyrimidine-Pyrazole Pyrimidinecarbonitrile Pyrimidinecarboxylate Pyrimidinecarboxylic Pyrimidinone Pyrimido-Indole Pyrrolidine-Pyrimidine Pyrrolopyrimidin-One Pyrrolopyrimidine Pyrrolopyrimidine-Carboxylate Pyrrolopyrimidine-Carboxylic-Acid Tetrahydrofuran-Pyrimidine Tetrahydropyrimidine Tetraoxatetradecan Thiazo-Pyrimidine Thiazolopyrimidine Thiazopyrimidine Thienopyrimidine Triazolopyrimidine Trichloropyrimidine Trifluoromethyl-Phenyl-Pyrimidin Trifluoromethyl-Pyrimidin-Amine Trifluoromethyl-Pyrimidin-Ol Trifluoromethylpyrimidine Vinylpyrimidine

By Parent Nucleus+−

Aromatic Heterocycles Azetidines Benzimidazoles Imidazoles Indazoles Indoles Indolines Morpholines Piperazines Piperidines Pyrazoles Pyridines Pyrrolidines Tetrahydroisoquinolines Thiazoles Thiophenols Triazoles

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